From twitter: @DrMichaelMosley My partner’s dodgy knee has improved since diet; not sure if cos less weight on it or inflammation down.
One of the things that I am particularly interested in is the anti-inflammatory effects of intermittent fasting (IF). A number of studies, in humans and in mice, have shown that IF reduces inflammatory markers (unlike high protein diets which seem to increase them). In a review paper for The Journal of Nutritional Biochemistry, March 2005, Dr Mark Mattson (whose work I cite frequently in my book as he is one the great researchers in this field) writes:
“Intermittent fasting and caloric restriction (CR) extend lifespan and increase resistance to age-related diseases in rodents and monkeys and improve the health of overweight humans. Both IF and CR enhance cardiovascular and brain functions and improve several risk factors for coronary artery disease and stroke including a reduction in blood pressure and increased insulin sensitivity…The beneficial effects of IF and CR result from at least two mechanisms — reduced oxidative damage and increased cellular stress resistance.”
I will go into the mechanisms around oxidative damage and what he means by cellular stress resistance at a later date if anyone out there is interested.