Excerpt from an article:
Research shows that chronic overeating places stress on the endoplasmic reticulum (ER)—the membranous network found inside the mitochondria of your cells. And when the ER receives more nutrients than it can process, it signals the cell to dampen the sensitivity of the insulin receptors on the surface of the cell.
Thus continuously eating more than your body really needs promotes insulin resistance by the mere fact that your cells are stressed by the work placed on them by the excess nutrients. This also helps explain why intermittent fasting (as well as other forms of calorie restriction) is so effective for reversing insulin resistance and increasing longevity.
Once your insulin resistance worsens, the concentration of glucose in your blood begins to rise, and elevated glucose contributes to the development of diabetes.
7:39 am
27 Jul 15